In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions

How early events in effector T cell (T(EFF)) subsets tune memory T cell (T(MEM)) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of T(EFF) and T(MEM) cells using in vivo pooled CRISPR screening, focusing on negative regulators o...

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Udgivet i:Cell
Main Authors: Huang, Hongling, Zhou, Peipei, Wei, Jun, Long, Lingyun, Shi, Hao, Dhungana, Yogesh, Chapman, Nicole M., Fu, Guotong, Saravia, Jordy, Raynor, Jana L., Liu, Shaofeng, Palacios, Gustavo, Wang, Yong-Dong, Qian, Chenxi, Yu, Jiyang, Chi, Hongbo
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101447/
https://ncbi.nlm.nih.gov/pubmed/33636132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.02.021
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