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EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8
Meiotic recombination in most mammals requires recombination hotspot activation through the action of the histone 3 Lys-4 and Lys-36 methyltransferase PRDM9 to ensure successful double-strand-break initiation and repair. Here we show that EWSR1, a protein whose role in meiosis was not previously cla...
Shranjeno v:
| izdano v: | Mol Biol Cell |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Cell Biology
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8098819/ https://ncbi.nlm.nih.gov/pubmed/33175657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-09-0604 |
| Oznake: |
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