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Difluorination of α-(bromomethyl)styrenes via I(I)/I(III) catalysis: facile access to electrophilic linchpins for drug discovery
Simple α-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor® and simple amine·HF complexes. Modul...
Shranjeno v:
| izdano v: | Chem Sci |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Royal Society of Chemistry
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8098697/ https://ncbi.nlm.nih.gov/pubmed/33996012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01132d |
| Oznake: |
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