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Difluorination of α-(bromomethyl)styrenes via I(I)/I(III) catalysis: facile access to electrophilic linchpins for drug discovery

Simple α-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor® and simple amine·HF complexes. Modul...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Häfliger, Joel, Livingstone, Keith, Daniliuc, Constantin G., Gilmour, Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society of Chemistry 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098697/
https://ncbi.nlm.nih.gov/pubmed/33996012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc01132d
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