Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins

The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histid...

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Udgivet i:Chem Sci
Main Authors: Rawale, Dattatraya Gautam, Thakur, Kalyani, Sreekumar, Pranav, T. K., Sajeev, A., Ramesh, Adusumalli, Srinivasa Rao, Mishra, Ram Kumar, Rai, Vishal
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2021
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8133000/
https://ncbi.nlm.nih.gov/pubmed/34040749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00335f
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