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Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Relaxases are metal-dependent nucleases that break and join DNA for the initiation and completion of conjugative bacterial gene transfer. Conjugation is the main process through which antibiotic resistance spreads among bacteria, with multidrug-resistant staphylococci and streptococci infections pos...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Pluta, Radoslaw, Boer, D. Roeland, Lorenzo-Díaz, Fabián, Russi, Silvia, Gómez, Hansel, Fernández-López, Cris, Pérez-Luque, Rosa, Orozco, Modesto, Espinosa, Manuel, Coll, Miquel
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559014/
https://ncbi.nlm.nih.gov/pubmed/28739894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702971114
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