Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

Relaxases are metal-dependent nucleases that break and join DNA for the initiation and completion of conjugative bacterial gene transfer. Conjugation is the main process through which antibiotic resistance spreads among bacteria, with multidrug-resistant staphylococci and streptococci infections pos...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pluta, Radoslaw, Boer, D. Roeland, Lorenzo-Díaz, Fabián, Russi, Silvia, Gómez, Hansel, Fernández-López, Cris, Pérez-Luque, Rosa, Orozco, Modesto, Espinosa, Manuel, Coll, Miquel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5559014/
https://ncbi.nlm.nih.gov/pubmed/28739894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702971114
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