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Linchpins empower promiscuous electrophiles to enable site-selective modification of histidine and aspartic acid in proteins
The conservation of chemoselectivity becomes invalid for multiple electrophilic warheads during protein bioconjugation. Consequently, it leads to unpredictable heterogeneous labeling of proteins. Here, we report that a linchpin can create a unique chemical space to enable site-selectivity for histid...
Tallennettuna:
| Julkaisussa: | Chem Sci |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Royal Society of Chemistry
2021
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8133000/ https://ncbi.nlm.nih.gov/pubmed/34040749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1sc00335f |
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