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Identification of protein recognition elements within heparin chains using enzymatic foot-printing in solution and on-line SEC/MS

Understanding molecular mechanisms governing interactions of glycosaminoglycans (such as heparin) with proteins remains challenging due to their enormous structural heterogeneity. Commonly accepted approaches seek to reduce the structural complexity by searching for “binding epitopes” within the lim...

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Bibliografiske detaljer
Udgivet i:Anal Chem
Main Authors: Niu, Chendi, Zhao, Yunlong, Bobst, Cedric E., Savinov, Sergey N., Kaltashov, Igor A.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095033/
https://ncbi.nlm.nih.gov/pubmed/32347711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00115
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