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Mass spectrometry reveals a multi-faceted role of glycosaminoglycan chains in factor Xa inactivation by antithrombin

Inhibition of factor Xa (fXa) by antithrombin (AT) enabled by heparin or heparan sulfate is critical for controlling blood coagulation. AT activation by heparin had been investigated extensively, while heparin interaction with the trapped AT/fXa intermediates received relatively little attention. We...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Minsky, Burcu B., Abzalimov, Rinat R., Niu, Chendi, Zhao, Yunlong, Kirsch, Zachary, Dubin, Paul L., Savinov, Sergey N., Kaltashov, Igor A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445383/
https://ncbi.nlm.nih.gov/pubmed/29999301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00199
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