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Mass spectrometry reveals a multi-faceted role of glycosaminoglycan chains in factor Xa inactivation by antithrombin
Inhibition of factor Xa (fXa) by antithrombin (AT) enabled by heparin or heparan sulfate is critical for controlling blood coagulation. AT activation by heparin had been investigated extensively, while heparin interaction with the trapped AT/fXa intermediates received relatively little attention. We...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6445383/ https://ncbi.nlm.nih.gov/pubmed/29999301 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00199 |
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