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H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: Is there a need for a top-down approach?
Hydrogen/deuterium exchange (HDX) combined with mass spectrometry (MS) detection has matured in recent years to become a powerful tool in structural biology and biophysics. Several limitations of this technique can and will be addressed by tapping into ever expanding arsenal of methods to manipulate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2805115/ https://ncbi.nlm.nih.gov/pubmed/19694441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac901366n |
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