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Conformer-specific characterization of nonnative protein states using hydrogen exchange and top-down mass spectrometry

Characterization of structure and dynamics of nonnative protein states is important for understanding molecular mechanisms of processes as diverse as folding, binding, aggregation, and enzyme catalysis to name just a few; however, selectively probing local minima within rugged energy landscapes rema...

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Autores principales: Wang, Guanbo, Abzalimov, Rinat R., Bobst, Cedric E., Kaltashov, Igor A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864316/
https://ncbi.nlm.nih.gov/pubmed/24277803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315029110
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