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Approach to Characterization of the Higher Order Structure of Disulfide-Containing Proteins Using Hydrogen/Deuterium Exchange and Top-Down Mass Spectrometry

[Image: see text] Top-down hydrogen/deuterium exchange (HDX) with mass spectrometric (MS) detection has recently matured to become a potent biophysical tool capable of providing valuable information on higher order structure and conformational dynamics of proteins at an unprecedented level of struct...

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Detalhes bibliográficos
Main Authors: Wang, Guanbo, Kaltashov, Igor A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144750/
https://ncbi.nlm.nih.gov/pubmed/24988145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac501789e
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