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Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches
Unlike small molecule drugs, the conformational properties of protein biopharmaceuticals in solution are influenced by a variety of factors that are not solely defined by their covalent chemical structure. Since the conformation (or higher order structure) of a protein is a major modulator of its bi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2628293/ https://ncbi.nlm.nih.gov/pubmed/18729476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac801214x |
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