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Detection and characterization of altered conformations of protein pharmaceuticals using complementary mass spectrometry-based approaches

Unlike small molecule drugs, the conformational properties of protein biopharmaceuticals in solution are influenced by a variety of factors that are not solely defined by their covalent chemical structure. Since the conformation (or higher order structure) of a protein is a major modulator of its bi...

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Bibliografiske detaljer
Main Authors: Bobst, Cedric E., Abzalimov, Rinat R., Houde, Damian, Kloczewiak, Marek, Mhatre, Rohin, Berkowitz, Steven A., Kaltashov, Igor A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2628293/
https://ncbi.nlm.nih.gov/pubmed/18729476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac801214x
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