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H/D exchange and mass spectrometry in the studies of protein conformation and dynamics: Is there a need for a top-down approach?

Hydrogen/deuterium exchange (HDX) combined with mass spectrometry (MS) detection has matured in recent years to become a powerful tool in structural biology and biophysics. Several limitations of this technique can and will be addressed by tapping into ever expanding arsenal of methods to manipulate...

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Bibliografiske detaljer
Main Authors: Kaltashov, Igor A., Bobst, Cedric E., Abzalimov, Rinat R.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805115/
https://ncbi.nlm.nih.gov/pubmed/19694441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac901366n
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