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Evaluation of Top-Down Mass Spectrometry and Ion-Mobility Spectroscopy as a Means of Mapping Protein-Binding Motifs within Heparin Chains

Identifying structural elements within heparin (as well as other glycosaminoglycan) chains that enable their interaction with a specific client protein remains a challenging task due to the high degree of both intra- and inter-chain heterogeneity exhibited by this polysaccharide. The new experimenta...

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Detalhes bibliográficos
Publicado no:Analyst
Main Authors: Zhao, Yunlong, Kaltashov, Igor A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160044/
https://ncbi.nlm.nih.gov/pubmed/32150181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0an00097c
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