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A new LC-MS based method to quantitate exogenous recombinant transferrin in cerebrospinal fluid: a potential approach for pharmacokinetic studies of transferrin-based therapeutics in the central nervous system

Transferrin (Tf) is an 80 kDa iron-binding protein which is viewed as a promising drug carrier to target the central nervous system due to its ability to penetrate the blood-brain barrier (BBB). Among the many challenges during the development of Tf-based therapeutics, sensitive and accurate quantit...

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Detalhes bibliográficos
Publicado no:Eur J Mass Spectrom (Chichester)
Main Authors: Wang, Shunhai, Bobst, Cedric E., Kaltashov, Igor A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808461/
https://ncbi.nlm.nih.gov/pubmed/26307718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1255/ejms.1365
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