Long Dissociation of Bictegravir from HIV-1 Integrase-DNA Complexes

The HIV integrase (IN) strand transfer inhibitor (INSTI) bictegravir (BIC) has a long dissociation half-life (t(1/2)) from wild-type IN-DNA complexes: BIC 163 h > dolutegravir (DTG) 96 h > raltegravir (RAL) 10 h > elvitegravir (EVG) 3.3 h. In cells, BIC had more durable antiviral activity a...

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發表在:Antimicrob Agents Chemother
Main Authors: White, Kirsten L., Osman, Nathan, Cuadra-Foy, Ernesto, Brenner, Bluma G., Shivakumar, Devleena, Campigotto, Federico, Tsiang, Manuel, Morganelli, Philip A., Novikov, Nikolai, Lazerwith, Scott E., Jin, Haolun, Niedziela-Majka, Anita
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2021
主題:
Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092912/
https://ncbi.nlm.nih.gov/pubmed/33649107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02406-20
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