Comparison of the Antiviral Activity of Bictegravir against HIV-1 and HIV-2 Isolates and Integrase Inhibitor-Resistant HIV-2 Mutants

We compared the activity of the integrase inhibitor bictegravir against HIV-1 and HIV-2 using a culture-based, single-cycle assay. Values of 50% effective concentrations ranged from 1.2 to 2.5 nM for 9 HIV-1 isolates and 1.4 to 5.6 nM for 15 HIV-2 isolates. HIV-2 integrase mutants G140S/Q148R and G1...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Smith, Robert A., Raugi, Dana N., Wu, Vincent H., Zavala, Christopher G., Song, Jennifer, Diallo, Khardiata Mbaye, Seydi, Moussa, Gottlieb, Geoffrey S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2019
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496081/
https://ncbi.nlm.nih.gov/pubmed/30803972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00014-19
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