MK-8591 (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture

There is a pressing need to identify more effective antiretroviral drugs for HIV-2 treatment. Here, we show that the investigational compound MK-8591 (4′-ethynyl-2-fluoro-2′-deoxyadenosine [EFdA]) is highly active against group A and B isolates of HIV-2; 50% effective concentrations [EC(50)] for HIV...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wu, Vincent H., Smith, Robert A., Masoum, Sara, Raugi, Dana N., Ba, Selly, Seydi, Moussa, Grobler, Jay A., Gottlieb, Geoffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527656/
https://ncbi.nlm.nih.gov/pubmed/28559249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00744-17
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