Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and lung injury. However, in pulmonary hypertension (PH), small pulmonary arteries are the focus of the pathology, and endothelial TRPV4 channels in this crucial ana...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Daneva, Zdravka, Marziano, Corina, Ottolini, Matteo, Chen, Yen-Lin, Baker, Thomas M., Kuppusamy, Maniselvan, Zhang, Aimee, Ta, Huy Q., Reagan, Claire E., Mihalek, Andrew D., Kasetti, Ramesh B., Shen, Yuanjun, Isakson, Brant E., Minshall, Richard D., Zode, Gulab S., Goncharova, Elena A., Laubach, Victor E., Sonkusare, Swapnil K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092599/
https://ncbi.nlm.nih.gov/pubmed/33879616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023130118
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