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Nitric Oxide–Dependent Feedback Loop Regulates Transient Receptor Potential Vanilloid 4 (TRPV4) Channel Cooperativity and Endothelial Function in Small Pulmonary Arteries

BACKGROUND: Recent studies demonstrate that spatially restricted, local Ca(2+) signals are key regulators of endothelium‐dependent vasodilation in systemic circulation. There are drastic functional differences between pulmonary arteries (PAs) and systemic arteries, but the local Ca(2+) signals that...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Marziano, Corina, Hong, Kwangseok, Cope, Eric L., Kotlikoff, Michael I., Isakson, Brant E., Sonkusare, Swapnil K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779028/
https://ncbi.nlm.nih.gov/pubmed/29275372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.117.007157
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