Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity

BACKGROUND: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca(2+) signaling in endothelial cells promotes vasodilation has led to the hypothesis that endothelial Ca(2+) signaling is compromised during obesity, but the underlying abnorm...

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Publicado en:Circulation
Main Authors: Ottolini, Matteo, Hong, Kwangseok, Cope, Eric L., Daneva, Zdravka, DeLalio, Leon J., Sokolowski, Jennifer D., Marziano, Corina, Nguyen, Nhiem Y., Altschmied, Joachim, Haendeler, Judith, Johnstone, Scott R., Kalani, Mohammad Y., Park, Min S., Patel, Rakesh P., Liedtke, Wolfgang, Isakson, Brant E., Sonkusare, Swapnil K.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195859/
https://ncbi.nlm.nih.gov/pubmed/32008372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.043385
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