Local Peroxynitrite Impairs Endothelial TRPV4 Channels and Elevates Blood Pressure in Obesity

BACKGROUND: Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca(2+) signaling in endothelial cells promotes vasodilation has led to the hypothesis that endothelial Ca(2+) signaling is compromised during obesity, but the underlying abnorm...

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Gepubliceerd in:Circulation
Hoofdauteurs: Ottolini, Matteo, Hong, Kwangseok, Cope, Eric L., Daneva, Zdravka, DeLalio, Leon J., Sokolowski, Jennifer D., Marziano, Corina, Nguyen, Nhiem Y., Altschmied, Joachim, Haendeler, Judith, Johnstone, Scott R., Kalani, Mohammad Y., Park, Min S., Patel, Rakesh P., Liedtke, Wolfgang, Isakson, Brant E., Sonkusare, Swapnil K.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195859/
https://ncbi.nlm.nih.gov/pubmed/32008372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.043385
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