Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and lung injury. However, in pulmonary hypertension (PH), small pulmonary arteries are the focus of the pathology, and endothelial TRPV4 channels in this crucial ana...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Daneva, Zdravka, Marziano, Corina, Ottolini, Matteo, Chen, Yen-Lin, Baker, Thomas M., Kuppusamy, Maniselvan, Zhang, Aimee, Ta, Huy Q., Reagan, Claire E., Mihalek, Andrew D., Kasetti, Ramesh B., Shen, Yuanjun, Isakson, Brant E., Minshall, Richard D., Zode, Gulab S., Goncharova, Elena A., Laubach, Victor E., Sonkusare, Swapnil K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092599/
https://ncbi.nlm.nih.gov/pubmed/33879616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023130118
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