Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension

Recent studies have focused on the contribution of capillary endothelial TRPV4 channels to pulmonary pathologies, including lung edema and lung injury. However, in pulmonary hypertension (PH), small pulmonary arteries are the focus of the pathology, and endothelial TRPV4 channels in this crucial ana...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Daneva, Zdravka, Marziano, Corina, Ottolini, Matteo, Chen, Yen-Lin, Baker, Thomas M., Kuppusamy, Maniselvan, Zhang, Aimee, Ta, Huy Q., Reagan, Claire E., Mihalek, Andrew D., Kasetti, Ramesh B., Shen, Yuanjun, Isakson, Brant E., Minshall, Richard D., Zode, Gulab S., Goncharova, Elena A., Laubach, Victor E., Sonkusare, Swapnil K.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092599/
https://ncbi.nlm.nih.gov/pubmed/33879616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2023130118
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