Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary Pseudomonas aeruginosa infection. To be fully active, IL-36γ is cleaved at its N-terminal region by proteases such as neutrophil elastase (NE) and cathepsi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:mBio
Egile Nagusiak: Peñaloza, Hernán F., Olonisakin, Tolani F., Bain, William G., Qu, Yanyan, van der Geest, Rick, Zupetic, Jill, Hulver, Mei, Xiong, Zeyu, Newstead, Michael W., Zou, Chunbin, Alder, Jonathan K., Ybe, Joel A., Standiford, Theodore J., Lee, Janet S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092289/
https://ncbi.nlm.nih.gov/pubmed/33824208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03336-20
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