Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection

Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promotes tissue damage. Conversely, mechanisms that constrain neutrophil serine protease activity protect against tissue damage but may have the untoward e...

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Vydáno v:Mucosal Immunol
Hlavní autoři: Zhao, Yani, Olonisakin, Tolani F., Xiong, Zeyu, Hulver, Mei, Sayeed, Sameera, Yu, Min Ting, Gregory, Alyssa D., Kochman, Elizabeth J., Chen, Bill B., Mallampalli, Rama K., Sun, Ming, Silverstein, Roy L., Stolz, Donna B., Shapiro, Steve D., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465063/
https://ncbi.nlm.nih.gov/pubmed/25492474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.120
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