Thrombospondin-1 restrains neutrophil granule serine protease function and regulates the innate immune response during Klebsiella pneumoniae infection

Neutrophil elastase (NE) and cathepsin G (CG) contribute to intracellular microbial killing but, if left unchecked and released extracellularly, promotes tissue damage. Conversely, mechanisms that constrain neutrophil serine protease activity protect against tissue damage but may have the untoward e...

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Detalhes bibliográficos
Publicado no:Mucosal Immunol
Principais autores: Zhao, Yani, Olonisakin, Tolani F., Xiong, Zeyu, Hulver, Mei, Sayeed, Sameera, Yu, Min Ting, Gregory, Alyssa D., Kochman, Elizabeth J., Chen, Bill B., Mallampalli, Rama K., Sun, Ming, Silverstein, Roy L., Stolz, Donna B., Shapiro, Steve D., Ray, Anuradha, Ray, Prabir, Lee, Janet S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4465063/
https://ncbi.nlm.nih.gov/pubmed/25492474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2014.120
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