Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis

Acute lung injury is characterized by excessive extracellular matrix proteolysis and neutrophilic inflammation. A major risk factor for lung injury is bacterial pneumonia. However, host factors that protect against pathogen-induced and host-sustained proteolytic injury following infection are poorly...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Qu, Yanyan, Olonisakin, Tolani, Bain, William, Zupetic, Jill, Brown, Rebecca, Hulver, Mei, Xiong, Zeyu, Tejero, Jesus, Shanks, Robert M.Q., Bomberger, Jennifer M., Cooper, Vaughn S., Zegans, Michael E., Ryu, Hyunryul, Han, Jongyoon, Pilewski, Joseph, Ray, Anuradha, Cheng, Zhenyu, Ray, Prabir, Lee, Janet S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821195/
https://ncbi.nlm.nih.gov/pubmed/29415890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96914
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