Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury

Mononuclear phagocyte recognition of apoptotic cells triggering suppressive cytokine signaling is a key event in inflammation resolution from injury. Mice deficient in thrombospondin-1 (thbs1(−/−)), an extracellular matrix glycoprotein that bridges cell-cell interactions, are prone to LPS-induced lu...

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Bibliographic Details
Main Authors: Zhao, Yani, Xiong, Zeyu, Lechner, Elizabeth J., Klenotic, Philip A., Hamburg, Brian J., Hulver, Mei, Khare, Anupriya, Oriss, Timothy, Mangalmurti, Nilam, Chan, Yvonne, Zhang, Yingze, Ross, Mark A., Stolz, Donna B., Rosengart, Matthew R., Pilewski, Joseph, Ray, Prabir, Ray, Anuradha, Silverstein, Roy L., Lee, Janet S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945733/
https://ncbi.nlm.nih.gov/pubmed/24045574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.63
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