Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury

Mononuclear phagocyte recognition of apoptotic cells triggering suppressive cytokine signaling is a key event in inflammation resolution from injury. Mice deficient in thrombospondin-1 (thbs1(−/−)), an extracellular matrix glycoprotein that bridges cell-cell interactions, are prone to LPS-induced lu...

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Главные авторы: Zhao, Yani, Xiong, Zeyu, Lechner, Elizabeth J., Klenotic, Philip A., Hamburg, Brian J., Hulver, Mei, Khare, Anupriya, Oriss, Timothy, Mangalmurti, Nilam, Chan, Yvonne, Zhang, Yingze, Ross, Mark A., Stolz, Donna B., Rosengart, Matthew R., Pilewski, Joseph, Ray, Prabir, Ray, Anuradha, Silverstein, Roy L., Lee, Janet S.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945733/
https://ncbi.nlm.nih.gov/pubmed/24045574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.63
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