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Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase In Lung CD103(+) But Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4(+) T cells and Promote Airway Tolerance
Dendritic cell (DC)-T cell interactions that underlie iTreg generation and airway tolerance are not well understood. Here we show that mice lacking CD11c(hi) lung DCs but containing pDCs fail tolerization with inhaled antigen and cannot support Foxp3 induction in vivo in naïve CD4(+) T cells. CD103(...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3694746/ https://ncbi.nlm.nih.gov/pubmed/23733880 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300193 |
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