Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary Pseudomonas aeruginosa infection. To be fully active, IL-36γ is cleaved at its N-terminal region by proteases such as neutrophil elastase (NE) and cathepsi...

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Detalles Bibliográficos
Publicado en:mBio
Main Authors: Peñaloza, Hernán F., Olonisakin, Tolani F., Bain, William G., Qu, Yanyan, van der Geest, Rick, Zupetic, Jill, Hulver, Mei, Xiong, Zeyu, Newstead, Michael W., Zou, Chunbin, Alder, Jonathan K., Ybe, Joel A., Standiford, Theodore J., Lee, Janet S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092289/
https://ncbi.nlm.nih.gov/pubmed/33824208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03336-20
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