Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary Pseudomonas aeruginosa infection. To be fully active, IL-36γ is cleaved at its N-terminal region by proteases such as neutrophil elastase (NE) and cathepsi...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:mBio
Main Authors: Peñaloza, Hernán F., Olonisakin, Tolani F., Bain, William G., Qu, Yanyan, van der Geest, Rick, Zupetic, Jill, Hulver, Mei, Xiong, Zeyu, Newstead, Michael W., Zou, Chunbin, Alder, Jonathan K., Ybe, Joel A., Standiford, Theodore J., Lee, Janet S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092289/
https://ncbi.nlm.nih.gov/pubmed/33824208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03336-20
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki