Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Interleukin-36γ (IL-36γ), a member of the IL-1 cytokine superfamily, amplifies lung inflammation and impairs host defense during acute pulmonary Pseudomonas aeruginosa infection. To be fully active, IL-36γ is cleaved at its N-terminal region by proteases such as neutrophil elastase (NE) and cathepsi...

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Bibliografski detalji
Izdano u:mBio
Glavni autori: Peñaloza, Hernán F., Olonisakin, Tolani F., Bain, William G., Qu, Yanyan, van der Geest, Rick, Zupetic, Jill, Hulver, Mei, Xiong, Zeyu, Newstead, Michael W., Zou, Chunbin, Alder, Jonathan K., Ybe, Joel A., Standiford, Theodore J., Lee, Janet S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2021
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092289/
https://ncbi.nlm.nih.gov/pubmed/33824208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03336-20
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