Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion

T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of autoimmunity, T cell exhaustion has been favorably correlated with long-term clinical outcome. Understanding the development of exhaustion in autoimmune settings may prov...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Zhu, Chen, Dixon, Karen O., Newcomer, Kathleen, Gu, Guangxiang, Xiao, Sheng, Zaghouani, Sarah, Schramm, Markus A., Wang, Chao, Zhang, Huiyuan, Goto, Kouichiro, Christian, Elena, Rangachari, Manu, Rosenblatt-Rosen, Orit, Okada, Hitoshi, Mak, Tak, Singer, Meromit, Regev, Aviv, Kuchroo, Vijay
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087420/
https://ncbi.nlm.nih.gov/pubmed/33931442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd2710
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