An IL-27/NFIL3 signaling axis drives Tim-3 and IL-10 expression and T cell dysfunction

The inhibitory receptor Tim-3 has emerged as a critical regulator of the T cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signaling pathways that drive Tim-3 expression. Here, we demonstrate that IL-27 induces NFIL3, which promotes perm...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhu, Chen, Sakuishi, Kaori, Xiao, Sheng, Sun, Zhiyi, Zaghouani, Sarah, Gu, Guangxiang, Wang, Chao, Tan, Dewar J., Wu, Chuan, Rangachari, Manu, Pertel, Thomas, Jin, Hyun-Tak, Ahmed, Rafi, Anderson, Ana C., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311884/
https://ncbi.nlm.nih.gov/pubmed/25614966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7072
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