TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs immunity and is detrimental to the outcome of M. tuberculosis infection. Here we p...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Jayaraman, Pushpa, Jacques, Miye K., Zhu, Chen, Steblenko, Katherine M., Stowell, Britni L., Madi, Asaf, Anderson, Ana C., Kuchroo, Vijay K., Behar, Samuel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4788425/
https://ncbi.nlm.nih.gov/pubmed/26967901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005490
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