IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection

IL-21 is produced predominantly by activated CD4(+) T cells and has pleiotropic effects on immunity via the IL-21 receptor (IL-21R), a member of the common gamma chain (γ(c)) cytokine receptor family. We show that IL-21 signaling plays a crucial role in T cell responses during Mycobacterium tubercul...

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Publicado en:Sci Rep
Autores principales: Booty, Matthew G., Barreira-Silva, Palmira, Carpenter, Stephen M., Nunes-Alves, Cláudio, Jacques, Miye K., Stowell, Britni L., Jayaraman, Pushpa, Beamer, Gillian, Behar, Samuel M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098191/
https://ncbi.nlm.nih.gov/pubmed/27819295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36720
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