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Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary messenger to bind and activate STING for subs...
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| Publicat a: | Signal Transduct Target Ther |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8085147/ https://ncbi.nlm.nih.gov/pubmed/33927185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00554-y |
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