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Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS
The detection of cytosolic DNA, derived from pathogens or host cells, by cytosolic receptors is essential for appropriate host immune responses. Cyclic GMP-AMP synthase (cGAS) is a newly identified cytosolic DNA receptor that produces cyclic GMP-AMP, which activates stimulator of interferon genes (S...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3792152/ https://ncbi.nlm.nih.gov/pubmed/24116191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076983 |
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