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TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which subsequently initiates downstr...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807518/ https://ncbi.nlm.nih.gov/pubmed/29426904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02936-3 |
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