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TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which subsequently initiates downstr...
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| 發表在: | Nat Commun |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807518/ https://ncbi.nlm.nih.gov/pubmed/29426904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-02936-3 |
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