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Cytosolic DNA sensing by cGAS: regulation, function, and human diseases
Sensing invasive cytosolic DNA is an integral component of innate immunity. cGAS was identified in 2013 as the major cytosolic DNA sensor that binds dsDNA to catalyze the synthesis of a special asymmetric cyclic-dinucleotide, 2′3′-cGAMP, as the secondary messenger to bind and activate STING for subs...
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| Yayımlandı: | Signal Transduct Target Ther |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8085147/ https://ncbi.nlm.nih.gov/pubmed/33927185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00554-y |
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