Spontaneous Formation of β-sheet Nano-barrels during the Early Aggregation of Alzheimer’s Amyloid Beta

Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we performed the first synergic in silico, in vitro and in vivo validations of the structure, dynamics and toxicity of Aβ42 oligo...

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Détails bibliographiques
Publié dans:Nano Today
Auteurs principaux: Sun, Yunxiang, Kakinen, Aleksandr, Wan, Xulin, Moriarty, Niamh, Hunt, Cameron P.J., Li, Yuhuan, Andrikopoulos, Nicholas, Nandakumar, Aparna, Davis, Thomas P., Parish, Clare L., Song, Yang, Ke, Pu Chun, Ding, Feng
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081394/
https://ncbi.nlm.nih.gov/pubmed/33936250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nantod.2021.101125
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