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Nucleation of β-rich Oligomers and β-barrels in the Early Aggregation of Human Islet Amyloid Polypeptide
The self-assembly of human islet amyloid polypeptide (hIAPP) into β-sheet rich amyloid aggregfiates is associated with pancreatic β-cell death in type 2 diabetes (T2D). Prior experimental studies of hIAPP aggregation reported the early accumulation of α-helical intermediates before the rapid convers...
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| Publicado no: | Biochim Biophys Acta Mol Basis Dis |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6310638/ https://ncbi.nlm.nih.gov/pubmed/30502402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2018.11.021 |
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