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Amyloid self-assembly of hIAPP8-20 via the accumulation of helical oligomers, α-helix to β-sheet transition, and formation of β-barrel intermediates

Self-assembly of human islet amyloid polypeptide (hIAPP) into β-sheet rich nanofibrils is associated with the pathogeny of type 2 diabetes. Soluble hIAPP is intrinsically disordered with N-terminal residues 8-17 as α-helix. To understand the contribution of the N-terminal helix to the aggregation pr...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Small
Päätekijät: Sun, Yunxiang, Kakinen, Aleksandr, Xing, Yanting, Faridi, Pouya, Nandakumar, Aparna, Purcell, Anthony W., Davis, Thomas P., Ke, Pu Chun, Ding, Feng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499678/
https://ncbi.nlm.nih.gov/pubmed/30908844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/smll.201805166
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