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β-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-β Aggregates

Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-agg...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sun, Yunxiang, Ge, Xinwei, Xing, Yanting, Wang, Bo, Ding, Feng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037789/
https://ncbi.nlm.nih.gov/pubmed/29985420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28649-7
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