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Direct Observation of β-barrel Intermediates in the Self-assembly of Toxic SOD1(28–38) and Absence in Non-toxic Glycine Mutants
Soluble low-molecular-weight oligomers formed during the early stage of amyloid aggregation are considered the major toxic species in amyloidosis. The structure-function relationship between oligomeric assemblies and the cytotoxicity in amyloid diseases are still elusive due to the heterogeneous and...
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| Vydáno v: | J Chem Inf Model |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7902411/ https://ncbi.nlm.nih.gov/pubmed/33445870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.0c01319 |
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