FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

SIMPLE SUMMARY: Overall survival outcomes, despite platinum-based chemotherapy, for patients with advanced ovarian cancer remains poor. Increased DNA repair capacity is a key route to platinum resistance in ovarian cancer. In the current study, we show that FEN1, a key player in DNA repair, is overe...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Mesquita, Katia A., Ali, Reem, Doherty, Rachel, Toss, Michael S., Miligy, Islam, Alblihy, Adel, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Hickson, Ian, Tatum, Natalie J., Rakha, Emad A., Madhusudan, Srinivasan
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070745/
https://ncbi.nlm.nih.gov/pubmed/33919707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081866
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