FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers

SIMPLE SUMMARY: Overall survival outcomes, despite platinum-based chemotherapy, for patients with advanced ovarian cancer remains poor. Increased DNA repair capacity is a key route to platinum resistance in ovarian cancer. In the current study, we show that FEN1, a key player in DNA repair, is overe...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Mesquita, Katia A., Ali, Reem, Doherty, Rachel, Toss, Michael S., Miligy, Islam, Alblihy, Adel, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M., Hickson, Ian, Tatum, Natalie J., Rakha, Emad A., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8070745/
https://ncbi.nlm.nih.gov/pubmed/33919707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13081866
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